HRID467357

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10868

Dicyclohexylcarbodiimide

C13H22N2

HCID89529

4,7-Methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-2-hydroxy-

C9H9NO3

结构：CC(C)(C)OC(=O)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)OCc1ccccc1

HCID11016011

未命名化合物

结构：Cc1ccc(S(=O)(=O)NC(=N)NCCC[C@@H](NC(=O)OC(C)(C)C)C(=O)O)cc1

HCID178427598

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(S(=O)(=O)NC(=N)NCCC[C@@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc2ccc(OCc3ccccc3)cc2)C(=O)OCc2ccccc2)cc1

HCID178427594

未命名化合物

PROCEDURE

实验过程

Using 2.32 g Boc-Tyr(Bzl)-OBzl, 2.37 g Boc-D-Arg(Tos)-OH, 0.75 g HONB and 1.14 g DCC, the desired product was obtained in exactly the same manner as in Example 1-(I).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f6b82140ef094319a7ad8cd8d01475b7
来源数据集: uspto-grants-1992_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05159061
来源说明: uspto-grants-1992_10

反应 SMILES

[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:18]([O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:19])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:6][CH:5]=1.[NH:35]([C:57]([O:59][C:60]([CH3:63])([CH3:62])[CH3:61])=[O:58])[C@@H:36]([C:54]([OH:56])=O)[CH2:37][CH2:38][CH2:39][NH:40][C:41](=[NH:53])[NH:42][S:43]([C:46]1[CH:52]=[CH:51][C:49]([CH3:50])=[CH:48][CH:47]=1)(=[O:45])=[O:44].C1C2C3C(=O)N(O)C(=O)C3C1C=C2.C1CCC(N=C=NC2CCCCC2)CC1>>[NH:35]([C:57]([O:59][C:60]([CH3:62])([CH3:63])[CH3:61])=[O:58])[C@@H:36]([C:54]([NH:1][C@H:2]([C:18]([O:20][CH2:21][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)=[O:19])[CH2:3][C:4]1[CH:5]=[CH:6][C:7]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:8][CH:9]=1)=[O:56])[CH2:37][CH2:38][CH2:39][NH:40][C:41](=[NH:53])[NH:42][S:43]([C:46]1[CH:47]=[CH:48][C:49]([CH3:50])=[CH:51][CH:52]=1)(=[O:44])=[O:45]