HRID467393

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)CCCCCCCCOC(c1ccccc1)(c1ccccc1)c1ccccc1

HCID42624366

未命名化合物

结构：COC(=O)CCCCCOC(c1ccccc1)(c1ccccc1)c1ccccc1

HCID67198977

未命名化合物

结构：COC(=O)CCCCCCCCCCCOC(c1ccccc1)(c1ccccc1)c1ccccc1

HCID67200799

未命名化合物

PRODUCTS

生成物

结构：O=C(O)CCCCCCCCCCCOC(c1ccccc1)(c1ccccc1)c1ccccc1

HCID10790077

Dodecanoic acid, 12-(triphenylmethoxy)-

C31H38O3

PROCEDURE

实验过程

Hydrolysis of the methyl ester of 15a, 15b, and 15c was carried out under basic conditions, followed by an acidic work up, during which the pH was maintained above 4 to prevent trityl deprotection. After recrystallization for solid product or flash chromatography for oil products, 6-trityloxyhexanoic acid 16a, 9-trityloxynonanoic acid 16b and 12-trityloxydodecanoic acid 16c were isolated, providing aliphatic side-chains that were ready to be coupled to 12 and 13.

WORKUP

后处理

temperatureduring which the pH was maintained above 4
customAfter recrystallization for solid product or flash chromatography for oil products, 6-trityloxyhexanoic acid 16a, 9-trityloxynonanoic acid 16b

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0c3f2de7ecae4ff483c3d51b7ba30cc8
来源数据集: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08623326B2
来源说明: uspto-grants-2014_01

反应 SMILES

C(OCCCCCC(OC)=O)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.COC(=O)CCCCCCCCOC(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.C[O:63][C:64](=[O:96])[CH2:65][CH2:66][CH2:67][CH2:68][CH2:69][CH2:70][CH2:71][CH2:72][CH2:73][CH2:74][CH2:75][O:76][C:77]([C:90]1[CH:95]=[CH:94][CH:93]=[CH:92][CH:91]=1)([C:84]1[CH:89]=[CH:88][CH:87]=[CH:86][CH:85]=1)[C:78]1[CH:83]=[CH:82][CH:81]=[CH:80][CH:79]=1>>[C:77]([O:76][CH2:75][CH2:74][CH2:73][CH2:72][CH2:71][CH2:70][CH2:69][CH2:68][CH2:67][CH2:66][CH2:65][C:64]([OH:96])=[O:63])([C:84]1[CH:85]=[CH:86][CH:87]=[CH:88][CH:89]=1)([C:90]1[CH:95]=[CH:94][CH:93]=[CH:92][CH:91]=1)[C:78]1[CH:79]=[CH:80][CH:81]=[CH:82][CH:83]=1