Acetonitrile → 5-Bromo-N-sec-butylpyrimidin-2-amine

Participants

Role	Name	HCID	Charge
Reactant	Acetonitrile	HCID 6342	—
Reactant	Sec-Butylamine	HCID 24874	—
Reactant	5-Bromo-2-chloropyrimidine	HCID 606665	—
Solvent	Ethyl Acetate	HCID 8857	—
Product	5-Bromo-N-sec-butylpyrimidin-2-amine	HCID 63873787	—

Reaction Conditions

Temperature	120 °C

Reaction Steps

In a sealed tube 2.00 g (10.3 mmol) 5-bromo-2-chloropyrimidine and 3.13 mL (31.0 mmol) sec-butylamin are added to 12 mL ACN. The reaction mixture is stirred at 120° C. for 2 h, then diluted with EtOAc and washed with water (2×). The org. phase is dried with MgSO4, filtered and the solvent is removed in vacuo.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08623860B2
Source dataset	uspto-grants-2014_01
ORD ID	ord-8962cf90801946fe8f040dce2e00d33d
Source note	uspto-grants-2014_01