HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 467467Generated: October 30, 2026
Ammonia → 3-(4-Chlorophenyl)-6-iodopyridazine
https://huagongshe.com/reaction/467467
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | 3-Chloro-6-(4-chlorophenyl)pyridazine | HCID 12257502 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-(4-Chlorophenyl)-6-iodopyridazine | HCID 86687913 | — |
Reaction Steps
20 ml ACN are added to 0.50 g (1.11 mmol) 3-(4-chlorophenyl)-6-chloropyridazine and 3.33 g (22.2 mmol) NaI before 189 μl fuming conc. HCl are added and the mixture is stirred at 80° C. for 4 h. The mixture is alkalised with aq. Ammonia solution (32%) diluted with water and extracted with EtOAc. The org. phases are combined, dried with Na2SO4 and the solvent is removed in vacuo. The resulting crude product is triturated with TBME.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08623860B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-f7303ff4a17b4f8ea9c6040a1d9dfb41 |
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| Source note | uspto-grants-2014_01 |
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