4-Benzyl-6-[(4-fluoro-3-methylphenoxy)methyl]-3-methyl-1,4-oxazepane → 6-[(4-Fluoro-3-methylphenoxy)methyl]-3-methyl-1,4-oxazepane

Participants

Reaction Conditions

Reaction Steps

A suspension of 4-benzyl-6-[(4-fluoro-3-methylphenoxy)methyl]-3-methyl-1,4-oxazepane (4-6, 36 mg, 0.11 mmol) and Pearlman's catalyst (wet 20% Pd(OH)2/C, 100 mg) in methanol (20 mL) was stirred under a hydrogen balloon at 23° C. for 2 h. The mixture was filtered and the filtrate concentrated to give 6-[(4-fluoro-3-methylphenoxy)methyl]-3-methyl-1,4-oxazepane (4-7) as a ˜1:1 mixture of diastereomers (colorless oil). LRMS m/z (M+H) 254.3 found, 254.2 required.

Provenance & Evidence