Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dabco | HCID 9237 | — |
| Reactant | HCID 86672979 | HCID 86672979 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86672978 | HCID 86672978 | 140.6% |
Reaction Steps
8.60 g of 1,4-diazabicyclo[2.2.2]octane is added to a solution of 25.5 g of the compound obtained in step 1 in 120 ml of DMF. It is degassed with nitrogen, then 0.703 g of palladium acetate is added and the reaction mixture is heated at 120° C. for 7 hours. EtOAc is added, then it is washed with water and with brine, dried over Na2SO4 and evaporated. After trituration of the solid residue with iso ether, 12.3 g of the expected compound is obtained in the form of a beige powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08623862B2 |
|---|
| Source dataset | uspto-grants-2014_01 |
|---|
| ORD ID | ord-e14f17833cd84265b3cd4d924e8db8ac |
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| Source note | uspto-grants-2014_01 |
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