Acetic Acid → HCID 89103754, compound

Participants

Reaction Conditions

Reaction Steps

2 ml of acetic acid and 0.64 g of iron(0) are added to 0.94 g of 1-[5-methyl-1-(4-nitrophenyl)-1H-pyrazol-4-yl]ethanone (Journal of Chemical Research, Synopses (1986), (5), 166-7) in 60 ml of EtOH/water mixture (65/35; v/v). It is heated at 75° C. for 2 hours. It is concentrated, filtered on Celite®, the filtrate is neutralized with saturated Na2CO3 and it is extracted with DCM. The organic phase is washed with water, with brine, it is dried over Na2SO4 and evaporated. 0.70 g of yellow powder is obtained.

Provenance & Evidence