6-Oxabicyclo[3.1.0]hexane → HCID 70927008, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 0.524 g of benzyl piperazine-1-carboxylate is cooled to 0° C., 0.2 g of 1,2-epoxycyclopentane is added and it is heated at 80° C. for four days. The reaction mixture is concentrated under vacuum and the residue is purified by silica gel chromatography, eluting with EtOAc/MeOH mixture. 0.32 g of the expected compound is obtained.

Provenance & Evidence