反应详情

A commercial solution of boron tribromide (1N in DCM, 0.4 mL, 0.4 mmol) was added to a solution of 4-[4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzoyl]piperazine-2,6-dione (which may be prepared in accordance with the experimental described in Example 4, step 5; 60 mg, 0.15 mmol) in dichloromethane (0.5 mL) placed under argon at −30° C. The reaction mixture was stirred at room temperature overnight and then diluted by addition of dichloromethane (10 mL) and a saturated solution of ammonium chloride (10 mL). After separation, the aqueous layer was extracted with dichloromethane (2×10 mL). The combined organic phases were dried over sodium sulfate, filtered and concentrated under vacuum. The residue was purified by chromatography on silica gel, using dichloromethane/methanol (98:2) as eluent. The title product was obtained as a white solid (35 mg, 60%).

1. custommay be prepared in accordance with the
2. customplaced under argon at −30° C
3. customAfter separation
4. extractionthe aqueous layer was extracted with dichloromethane (2×10 mL)
5. dry with materialThe combined organic phases were dried over sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated under vacuum
8. customThe residue was purified by chromatography on silica gel