反应详情

Dichloro (1,2-diaminocyclohexane)platinum (II) was synthesized as described by Gale et al, Research Communications in Chemical Pathology and Pharmacology, Volume 7, No. 3, Pages 529-538, March 1974. Thus, Potassium tetrachloroplatinite, K2Pt Cl4 (20 mM) in 75 ml water was mixed with 1,2-diaminocyclohexane (20 mM) for three hours at room temperature. The insoluble product was removed by filtration, washed with water and then with methanol, and oven-dried. The yield was approximately 90% of theory. The product was then purified by dissolution in dimethylformamide, filtration, and addition of three volumes of methanol or 0.1 N HCl. This product was filtered, washed, and dried as above. The yield in purification was 47%.

1. customThe insoluble product was removed by filtration
2. washwashed with water
3. dry with materialwith methanol, and oven-dried
4. customThe product was then purified by dissolution in dimethylformamide
5. filtrationfiltration, and addition of three volumes of methanol or 0.1 N HCl
6. filtrationThis product was filtered
7. washwashed
8. customdried as above
9. customThe yield in purification