Methanol → HCID 178514106, compound

Participants

Reaction Steps

A mixture of imidazole 12 (29 mg, 0.076 mmol), trimethylsilyl isocyanate (18 mg, 0.15 mmol) and triethylamine (31 mg, 0.30 mmol) in tetrahydrofuran (1 mL) was stirred at r.t. for 4 h. Methanol (1 mL) was added and the mixture was stirred at r.t for 1 h. The solvents were removed in vacuo and chromatographic purification (ethyl acetate-hexane) of the residue gave urea 15 (21 mg, 64%) as a colorless oil. LCMS m/e (M+H+)=425.2.

Provenance & Evidence