HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-3-nitroaniline → Tert-butyl 4-fluoro-3-nitrophenylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-3-nitroaniline | HCID 67768 | — |
| Reactant | Carbonic acid, bis(1,1-dimethylethyl) ester | HCID 10219638 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Tert-butyl 4-fluoro-3-nitrophenylcarbamate | HCID 11118665 | 88% |
Reaction Steps
A mixture of 4-fluoro-3-nitroaniline (30 g, 0.192 mol), di-t-butylcarbonate (84 g, 0.384 mol) was stirred in ethanol (300 mL) at r.t. for 1 week. The solvents were removed in vacuo and chromatographic purification (ethyl acetate-hexane) of the residue gave tert-butyl 4-fluoro-3-nitrophenylcarbamate (43 g, 88%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08623857B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-2b71530c32fc49d6a1ad2b00fc401a52 |
| Source note | uspto-grants-2014_01 |