1,2-Difluoro-3-nitrobenzene → HCID 67992187, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of difluoronitrobenzene (0.34 mL, 3.10 mmol), methyl isonipecotate (0.51 mL, 3.78 mmol), and diisopropylethylamine (1.08 mL, 6.20 mmol) in acetonitrile (15 mL) was heated at 80° C. overnight. The solvents were removed in vacuo. Chromatographic purification (20% ethyl acetate:hexane) of the residue gave Int-20a (0.85 g, 97%) as a yellow oil.

Provenance & Evidence