2-Bromo-5-(trifluoromethyl)pyridine → 6-((2S,3'S)-2-Methyl-[1,3']bipyrrolidinyl-1'-yl)-2-(5-trifluoromethyl-pyridin-2-yl)-1,2,3,4-tetrahydro-isoquinoline

HRID 467562Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 467562
[CH3:1][C@H:2]1[CH2:6][CH2:5][CH2:4][N:3]1[C@H:7]1[CH2:11][CH2:10][N:9]([C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[CH2:18][NH:17][CH2:16][CH2:15]3)[CH2:8]1.Br[C:23]1[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][N:24]=1>>[CH3:1][C@H:2]1[CH2:6][CH2:5][CH2:4][N:3]1[C@H:7]1[CH2:11][CH2:10][N:9]([C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[CH2:18][N:17]([C:23]2[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][N:24]=2)[CH2:16][CH2:15]3)[CH2:8]1

Komponenten

3

Edukt 2

HCID 27364342-Bromo-5-(trifluoromethyl)pyridineHCID 674693316-((2S,3'S)-2-Methyl-[1,3']bipyrrolidinyl-1'-yl)-1,2,3,4-tetrahydro-isoquinoline

Produkt 1

HCID 546699156-((2S,3'S)-2-Methyl-[1,3']bipyrrolidinyl-1'-yl)-2-(5-trifluoromethyl-pyridin-2-yl)-1,2,3,4-tetrahydro-isoquinoline

Versuchsvorschrift

The title compound was synthesized in substantially the same way as Example 1 by condensation of 6-((2S,3′S)-2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-1,2,3,4-tetrahydro-isoquinoline with 2-bromo-5-trifluoromethyl-pyridine.

Quellen und Nachweise

ORD-Eintrag
ord-ed114f4dee704506bc2f356be2ee2c26
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08623877B2

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