2-Bromo-6-methylpyridine → 6-((2S,3'S)-2-Methyl-[1,3']bipyrrolidinyl-1'-yl)-2-(6-methyl-pyridin-2-yl)-1,2,3,4-tetrahydro-isoquinoline

HRID 467564ノート

反応式

HRID 467564 の反応式
[CH3:1][C@H:2]1[CH2:6][CH2:5][CH2:4][N:3]1[C@H:7]1[CH2:11][CH2:10][N:9]([C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[CH2:18][NH:17][CH2:16][CH2:15]3)[CH2:8]1.Br[C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([CH3:29])[N:24]=1>>[CH3:1][C@H:2]1[CH2:6][CH2:5][CH2:4][N:3]1[C@H:7]1[CH2:11][CH2:10][N:9]([C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[CH2:18][N:17]([C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([CH3:29])[N:24]=2)[CH2:16][CH2:15]3)[CH2:8]1

参加物

3

反応物 2

HCID 792052-Bromo-6-methylpyridineHCID 674693316-((2S,3'S)-2-Methyl-[1,3']bipyrrolidinyl-1'-yl)-1,2,3,4-tetrahydro-isoquinoline

生成物 1

HCID 546700046-((2S,3'S)-2-Methyl-[1,3']bipyrrolidinyl-1'-yl)-2-(6-methyl-pyridin-2-yl)-1,2,3,4-tetrahydro-isoquinoline

実験手順

The title compound was synthesized in substantially the same way as Example 1 by condensation of 6-((2S,3′S)-2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-1,2,3,4-tetrahydro-isoquinoline with 2-bromo-6-methyl-pyridine.

出典と根拠

ORDレコード
ord-1bff68defbd54461a7d83aefbadac865
出典データセット
uspto-grants-2014_01
特許番号
US08623877B2

反応ノート

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