2,5-Dibromopyrimidine → 2-(2-Bromo-pyrimidin-5-yl)-6-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-1,2,3,4-tetrahydro-isoquinoline

HRID 467565ノート

反応式

HRID 467565 の反応式
[CH3:1][C@H:2]1[CH2:6][CH2:5][CH2:4][N:3]1[C@H:7]1[CH2:11][CH2:10][N:9]([C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[CH2:18][NH:17][CH2:16][CH2:15]3)[CH2:8]1.[Br:22][C:23]1[N:28]=[CH:27][C:26](Br)=[CH:25][N:24]=1>>[Br:22][C:23]1[N:28]=[CH:27][C:26]([N:17]2[CH2:16][CH2:15][C:14]3[C:19](=[CH:20][CH:21]=[C:12]([N:9]4[CH2:10][CH2:11][C@H:7]([N:3]5[CH2:4][CH2:5][CH2:6][C@@H:2]5[CH3:1])[CH2:8]4)[CH:13]=3)[CH2:18]2)=[CH:25][N:24]=1

参加物

3

反応物 2

HCID 109555882,5-DibromopyrimidineHCID 674693316-((2S,3'S)-2-Methyl-[1,3']bipyrrolidinyl-1'-yl)-1,2,3,4-tetrahydro-isoquinoline

生成物 1

HCID 546700052-(2-Bromo-pyrimidin-5-yl)-6-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-1,2,3,4-tetrahydro-isoquinoline

実験手順

The title compound was synthesized in substantially the same way as Example 1 by condensation of 6-((2S,3′S)-2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-1,2,3,4-tetrahydro-isoquinoline with 2,5-dibromo-pyrimidine.

出典と根拠

ORDレコード
ord-758624c0c876414797d5919ceb99a3ac
出典データセット
uspto-grants-2014_01
特許番号
US08623877B2

反応ノート

読み込み中…