2-Bromo-6-methyl-4-(trifluoromethyl)pyridine → HCID 54670094, compound

HRID 467571Notes

Reaction equation

HRID 467571 reaction equation
[CH3:1][C@H:2]1[CH2:6][CH2:5][CH2:4][N:3]1[C@H:7]1[CH2:11][CH2:10][N:9]([C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[CH2:18][NH:17][CH2:16][CH2:15]3)[CH2:8]1.Br[C:23]1[CH:28]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:26]=[C:25]([CH3:33])[N:24]=1>>[CH3:1][C@H:2]1[CH2:6][CH2:5][CH2:4][N:3]1[C@H:7]1[CH2:11][CH2:10][N:9]([C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[CH2:18][N:17]([C:23]2[CH:28]=[C:27]([C:29]([F:30])([F:32])[F:31])[CH:26]=[C:25]([CH3:33])[N:24]=2)[CH2:16][CH2:15]3)[CH2:8]1

Participants

3

Reactant 2

HCID 178623252-Bromo-6-methyl-4-(trifluoromethyl)pyridineHCID 674693316-((2S,3'S)-2-Methyl-[1,3']bipyrrolidinyl-1'-yl)-1,2,3,4-tetrahydro-isoquinoline

Product 1

HCID 54670094HCID 54670094, compound

Procedure

The title compound was synthesized in substantially the same way as Example 1 by condensation of 6-((2S,3′S)-2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-1,2,3,4-tetrahydro-isoquinoline with 2-Bromo-6-methyl-4-trifluoromethyl-pyridine.

Sources & evidence

ORD record
ord-16ac5a35496b455b8277bf3e4fc71d7f
Source dataset
uspto-grants-2014_01
Patent number
US08623877B2

Reaction notes

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