HCID 67238193, compound → HCID 178480677, compound

Participants

Reaction Steps

5-(2,6-Dichloro-phenylcarbamoyl)-6,6-dimethyl-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-2-carboxylic acid ethyl ester (0.6 g, 0.97 mmol) was dissolved in methanol (20 mL), treated with TEA (0.67 mL, 4.85 mmol, 5 eq) and stirred overnight at room temperature. After evaporation of the solvent, the solid was treated with diethyl ether and filtered to afford 0.28 g (yield 76%) of the title compound.

Provenance & Evidence