HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 467603Generated: October 31, 2026
Piperidine → 4-Piperidin-1-yl-but-2-enoic acid methyl ester
https://huagongshe.com/reaction/467603
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2-Butenoic acid, 4-bromo-, methyl ester | HCID 5369175 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Piperidin-1-yl-but-2-enoic acid methyl ester | HCID 57229306 | — |
Reaction Steps
Methyl 4-bromocrotonate (2 g, 11.2 mmol) was dissolved in dichloromethane (20 mL) and cooled to 0° C. Piperidine (1.11 mL, 11.2 mmol) was added slowly. The mixture was stirred at 0° C. for 1 hour. The solvent was removed in vacuo. The crude material was used as is. MS m/z 184 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08623883B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-d1677ae777ea4a3fa9ec7b80966ee348 |
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| Source note | uspto-grants-2014_01 |
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