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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 467654Generated: October 30, 2026

Cyclopropylamine → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid (3-cyclopropylcarbamoyl-1-methyl-1H-pyrazol-4-yl)-amide

https://huagongshe.com/reaction/467654

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyclopropylamineHCID 69828—
Reactant4-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-1-methyl-1H-pyrazole-3-carboxylic acid methyl esterHCID 70099200—
Product6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid (3-cyclopropylcarbamoyl-1-methyl-1H-pyrazol-4-yl)-amideHCID 7011653024%

Reaction Steps

According to the general method described in step 5 of example 27, reaction of cyclopropylamine with 4-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester provided the title compound (24%) as amorphous yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08623866B2
Source datasetuspto-grants-2014_01
ORD IDord-a2d1664d9afc41e4af218be639fdc01e
Source noteuspto-grants-2014_01