HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Methylamino)-1-propanol → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid {3-[(3-hydroxy-propyl)-methyl-carbamoyl]-1-methyl-1H-pyrazol-4-yl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Methylamino)-1-propanol | HCID 10148986 | — |
| Reactant | 4-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester | HCID 70099200 | — |
| Product | 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid {3-[(3-hydroxy-propyl)-methyl-carbamoyl]-1-methyl-1H-pyrazol-4-yl}-amide | HCID 58548313 | 39% |
Reaction Steps
According to the general method described in step 5 of example 27, reaction of 3-methylamino-propan-1-ol with 4-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester provided the title compound (39%) as amorphous yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08623866B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-45e30e068b4b4d69bb99b0f1bab33f3b |
| Source note | uspto-grants-2014_01 |