HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Oxa-6-azaspiro[3.3]heptane → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [1-methyl-3-(2-oxa-6-aza-spiro[3.3]heptane-6-carbonyl)-1H-pyrazol-4-yl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Oxa-6-azaspiro[3.3]heptane | HCID 23111887 | — |
| Reactant | 4-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester | HCID 70099200 | — |
| Product | 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [1-methyl-3-(2-oxa-6-aza-spiro[3.3]heptane-6-carbonyl)-1H-pyrazol-4-yl]-amide | HCID 58548407 | 5% |
Reaction Steps
According to the general method described in step 5 of example 27, reaction of 2-oxa-6-aza-spiro[3.3]heptane with 4-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester provided the title compound (5%) as sticky yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08623866B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-92208373f61943a29d04ed88114a40dc |
| Source note | uspto-grants-2014_01 |