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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 467677Generated: October 26, 2026

3-(Dimethylamino)pyrrolidine → 6-Cyclopropyl-N-[4-(3-dimethylamino-pyrrolidine-1-carbonyl)-pyridin-3-yl]-3-(pyrimidin-5-ylamino)-pyridine-2-carboximidic acid

https://huagongshe.com/reaction/467677

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Dimethylamino)pyrrolidineHCID 2758519—
Reactant3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acidHCID 70098054—
Product6-Cyclopropyl-N-[4-(3-dimethylamino-pyrrolidine-1-carbonyl)-pyridin-3-yl]-3-(pyrimidin-5-ylamino)-pyridine-2-carboximidic acidHCID 17848294413%

Reaction Steps

According to the general method described above (step 3), reaction of 3-dimethylamino-pyrrolidine with 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid provided the title compound (13%) as sticky yellow solid

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08623866B2
Source datasetuspto-grants-2014_01
ORD IDord-d200c9cdf15a4796a17503409a5d4c82
Source noteuspto-grants-2014_01