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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 467682Generated: October 25, 2026

3,3-Difluoropyrrolidine → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [4-(3,3-difluoro-pyrrolidine-1-carbonyl)-pyridin-3-yl]-amide

https://huagongshe.com/reaction/467682

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,3-DifluoropyrrolidineHCID 2782827—
Reactant3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acidHCID 70098054—
Product6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [4-(3,3-difluoro-pyrrolidine-1-carbonyl)-pyridin-3-yl]-amideHCID 5476056727%

Reaction Steps

According to the general method described in step 3 of example 53, reaction of 3,3-difluoro-pyrrolidine with 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid provided the title compound (27%) as amourphous light yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08623866B2
Source datasetuspto-grants-2014_01
ORD IDord-16acc821bba145a6ae3ffc6500471682
Source noteuspto-grants-2014_01