Cyclopropylamine → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid (4-cyclopropylcarbamoyl-pyridin-3-yl)-amide

HRID 467683Notes

Reaction equation

HRID 467683 reaction equation
[CH:1]1([NH2:4])[CH2:3][CH2:2]1.[CH:5]1([C:8]2[N:13]=[C:12]([C:14]([NH:16][C:17]3[CH:25]=[N:24][CH:23]=[CH:22][C:18]=3[C:19](O)=[O:20])=[O:15])[C:11]([NH:26][C:27]3[CH:28]=[N:29][CH:30]=[N:31][CH:32]=3)=[CH:10][CH:9]=2)[CH2:7][CH2:6]1>>[CH:1]1([NH:4][C:19]([C:18]2[CH:22]=[CH:23][N:24]=[CH:25][C:17]=2[NH:16][C:14]([C:12]2[C:11]([NH:26][C:27]3[CH:28]=[N:29][CH:30]=[N:31][CH:32]=3)=[CH:10][CH:9]=[C:8]([CH:5]3[CH2:7][CH2:6]3)[N:13]=2)=[O:15])=[O:20])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 700980543-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid

Product 1

HCID 547605686-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid (4-cyclopropylcarbamoyl-pyridin-3-yl)-amideYield 28%

Procedure

According to the general method described in step 3 of example 53, reaction of cyclopropylamine with 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid provided the title compound (28%) as yellow powder.

Sources & evidence

ORD record
ord-eec09772622a4d659984876876c231fa
Source dataset
uspto-grants-2014_01
Patent number
US08623866B2

Reaction notes

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