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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 467688Generated: October 30, 2026

3-Methoxypyrrolidine → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [4-(3-methoxy-pyrrolidine-1-carbonyl)-pyridin-3-yl]-amide

https://huagongshe.com/reaction/467688

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-MethoxypyrrolidineHCID 11355447—
Reactant3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acidHCID 70098054—
Product6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [4-(3-methoxy-pyrrolidine-1-carbonyl)-pyridin-3-yl]-amideHCID 5476075918%

Reaction Steps

According to the general method described in step 3 of example 53, reaction of 3-methoxy-pyrrolidine with 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid provided the title compound (18%) as off-white powder.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08623866B2
Source datasetuspto-grants-2014_01
ORD IDord-a0d087918d8a4bbaa382818bc7912ca5
Source noteuspto-grants-2014_01