反应详情

To a solution of 3.4 g of ethyl 2-p-chlorophenyl-5-phenylthio-4-thiazoleacetate in 100 ml of methanol was added 15 ml of 3 N aqueous potassium hydroxide. The mixture was stirred at room temperature for 3 hours. The solvent was distilled off under reduced pressure and water was added to the residue. The solution was acidified with hydrochloric acid. The white precipitated solid was filtered off, washed with water, dried and recrystallized from ethanol to give 2.3 g of the title compound, melting at 191°-193° C.

1. distillationThe solvent was distilled off under reduced pressure and water
2. additionwas added to the residue
3. customThe white precipitated solid
4. filtrationwas filtered off
5. washwashed with water
6. customdried
7. customrecrystallized from ethanol