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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 467713Generated: October 25, 2026

2,2-Dimethylpyrrolidine → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [4-(2,2-dimethyl-pyrrolidine-1-carbonyl)-pyridin-3-yl]-amide

https://huagongshe.com/reaction/467713

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,2-DimethylpyrrolidineHCID 414773—
Reactant3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acidHCID 70098054—
Product6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [4-(2,2-dimethyl-pyrrolidine-1-carbonyl)-pyridin-3-yl]-amideHCID 5854825823%

Reaction Steps

According to the general method described in step 3 of example 53, reaction of 2,2-dimethylpyrrolidine with 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid provided the title compound (23%) as sticky yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08623866B2
Source datasetuspto-grants-2014_01
ORD IDord-f791540da91f452da2572cd478f61623
Source noteuspto-grants-2014_01