反应详情

To 1.0 g of 2-p-chlorophenyl-5-p-chlorophenylthio-4-thiazoleacetic acid were added 10 ml of benzene and 2.0 ml of thionyl chloride, and the mixture was refluxed for 30 minutes. The solvent and the excess thionyl chloride were distilled off under reduced pressure. To the residue was added 20 ml of ethanol and stirred at room temperature for 1 hour and then the solvent was distilled off under reduced pressure. Recrystallization of the residue from ethanol gave 0.8 g of the title compound, melting at 103°-104° C.

1. temperaturethe mixture was refluxed for 30 minutes
2. distillationThe solvent and the excess thionyl chloride were distilled off under reduced pressure
3. additionTo the residue was added 20 ml of ethanol
4. distillationthe solvent was distilled off under reduced pressure
5. customRecrystallization of the residue from ethanol