Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 467729Generated: October 25, 2026

Oxetan-3-amine hydrochloride → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [4-(oxetan-3-ylcarbamoyl)-pyridin-3-yl]-amide

https://huagongshe.com/reaction/467729

Reaction equation

Participants

RoleNameHCIDCharge
ReactantOxetan-3-amine hydrochlorideHCID 23062080—
Reactant3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acidHCID 70098928—
Product6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [4-(oxetan-3-ylcarbamoyl)-pyridin-3-yl]-amideHCID 5854821758%

Reaction Steps

According to the procedure described in step 3 of example 99, 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid (example 99, step 2) was reacted with oxetan-3-amine hydrochloride, providing the title compound as yellow solid (58%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08623866B2
Source datasetuspto-grants-2014_01
ORD IDord-bbba5cc4a98a4f4ea8f6cd009573e343
Source noteuspto-grants-2014_01