Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Methoxy-2-methylpropan-1-amine → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [4-(2-methoxy-2-methyl-propylcarbamoyl)-pyridin-3-yl]-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Methoxy-2-methylpropan-1-amine | HCID 11789141 | — |
| 반응물 | 3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid | HCID 70098928 | — |
| 생성물 | 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [4-(2-methoxy-2-methyl-propylcarbamoyl)-pyridin-3-yl]-amide | HCID 58548393 | 71% |
반응 단계
According to the procedure described in step 3 of example 99, 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid (example 99, step 2) was reacted with 2-methoxy-2-methylpropan-1-amine, providing the title compound as yellow solid (71%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08623866B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-9ea9d7d233a44b46a7253bcb86f601df |
| 출처 메모 | uspto-grants-2014_01 |