3-Amino-3-methyloxetane → HCID 58548253, compound

HRID 467736Notes

Reaction equation

HRID 467736 reaction equation
[CH:1]1([C:4]2[N:9]=[C:8]([C:10]([NH:12][C:13]3[CH:21]=[N:20][CH:19]=[CH:18][C:14]=3[C:15](O)=[O:16])=[O:11])[C:7]([NH:22][C:23]3[CH:24]=[N:25][CH:26]=[N:27][CH:28]=3)=[N:6][CH:5]=2)[CH2:3][CH2:2]1.[CH3:29][C:30]1([NH2:34])[CH2:33][O:32][CH2:31]1>>[CH3:29][C:30]1([NH:34][C:15]([C:14]2[CH:18]=[CH:19][N:20]=[CH:21][C:13]=2[NH:12][C:10]([C:8]2[C:7]([NH:22][C:23]3[CH:24]=[N:25][CH:26]=[N:27][CH:28]=3)=[N:6][CH:5]=[C:4]([CH:1]3[CH2:2][CH2:3]3)[N:9]=2)=[O:11])=[O:16])[CH2:33][O:32][CH2:31]1

Participants

3

Reactant 2

HCID 468357253-Amino-3-methyloxetaneHCID 700989283-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid

Product 1

HCID 58548253HCID 58548253, compound

Procedure

According to the procedure described in step 3 of example 99, 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid (example 99, step 2) was reacted with 3-methyloxetan-3-amine, providing the title compound was obtained as yellow solid (44%).

Sources & evidence

ORD record
ord-ef4ec29c4dc640e4a95a218ccd7165ed
Source dataset
uspto-grants-2014_01
Patent number
US08623866B2

Reaction notes

Loading…