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温度

0 °C

25 g of the latter hydrobromide were dissolved in 250 ml of hot water and the solution was cooled to 0° C. and made alkaline with 40 ml of 2 N sodium hydroxide. The mixture was extracted 3 times with 100 ml of ethyl acetate and the organic extracts were washed with water until the wash water had a pH of 7 to 8. The extracts were dried over sodium sulfate, were filtered and evaporated to dryness under reduced pressure to obtain 19 g of N-phenethyl-3,4-dimethoxyphenethylamine.

1. extractionThe mixture was extracted 3 times with 100 ml of ethyl acetate
2. washthe organic extracts were washed with water until the wash water
3. dry with materialThe extracts were dried over sodium sulfate
4. filtrationwere filtered
5. customevaporated to dryness under reduced pressure