4-amino-N,1-dimethyl-1H-pyrazole-5-carboxamide → 6-Chloro-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid (1-methyl-5-methylcarbamoyl-1H-pyrazol-4-yl)-amide

HRID 467749Notes

Reaction equation

HRID 467749 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]([OH:10])=O)[C:5]([NH:11][C:12]2[CH:13]=[N:14][CH:15]=[N:16][CH:17]=2)=[CH:4][CH:3]=1.[CH3:18][NH:19][C:20]([C:22]1[N:23]([CH3:28])[N:24]=[CH:25][C:26]=1[NH2:27])=[O:21]>>[CH3:28][N:23]1[C:22]([C:20](=[O:21])[NH:19][CH3:18])=[C:26]([NH:27][C:8]([C:6]2[C:5]([NH:11][C:12]3[CH:13]=[N:14][CH:15]=[N:16][CH:17]=3)=[CH:4][CH:3]=[C:2]([Cl:1])[N:7]=2)=[O:10])[CH:25]=[N:24]1

Participants

3

Reactant 2

HCID 64853704-amino-N,1-dimethyl-1H-pyrazole-5-carboxamideHCID 866601946-Chloro-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid

Product 1

HCID 547601956-Chloro-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid (1-methyl-5-methylcarbamoyl-1H-pyrazol-4-yl)-amide

Procedure

The product was obtained starting from 6-chloro-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid (30 mg, 0.12 mmol) and 4-amino-2-methyl-2H-pyrazole-3-carboxylic acid methylamide (24 mg, 0.15 mmol) according to the method described in example 64, step 6 as yellow solid (29 mg, 62%).

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-2e7a737d943c421daff8a92ffbfa4a14
Source dataset
uspto-grants-2014_01
Patent number
US08623866B2

Reaction notes

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