Furan-2-boronic acid → Ethyl 3-amino-6-(tetrahydrofuran-3-yl)picolinate

HRID 467750Notes

Reaction equation

HRID 467750 reaction equation
[NH2:1][C:2]1[C:3]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[N:4][C:5](Br)=[CH:6][CH:7]=1.[O:14]1[CH:18]=[CH:17][CH:16]=[C:15]1B(O)O>>[NH2:1][C:2]1[C:3]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[N:4][C:5]([CH:16]2[CH2:17][CH2:18][O:14][CH2:15]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 2734357Furan-2-boronic acidHCID 25137688Ethyl 3-amino-6-bromopicolinate

Product 1

HCID 70096465Ethyl 3-amino-6-(tetrahydrofuran-3-yl)picolinate

Procedure

According to step 1 and 2 of example 96, the title compound was prepared starting from ethyl 3-amino-6-bromopicolinate and furan-2-ylboronic acid. Light yellow solid.

Sources & evidence

ORD record
ord-2816017c280d4690ad35679656f727e2
Source dataset
uspto-grants-2014_01
Patent number
US08623866B2

Reaction notes

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