Mucobromic Acid → 5-Bromo-2-cyclobutylpyrimidine-4-carboxylic acid

HRID 467754Notes

Reaction equation

[CH:1]1([C:5]([NH2:7])=[NH:6])[CH2:4][CH2:3][CH2:2]1.[C:8]([OH:16])(=[O:15])/[C:9](=[C:11](\[CH:13]=O)/[Br:12])/Br>>[Br:12][C:11]1[C:9]([C:8]([OH:16])=[O:15])=[N:6][C:5]([CH:1]2[CH2:4][CH2:3][CH2:2]2)=[N:7][CH:13]=1

Participants

Reactant 2

HCID 3033972Mucobromic Acid

HCID 4057533Cyclobutanecarboxamidine

Product 1

HCID 700971745-Bromo-2-cyclobutylpyrimidine-4-carboxylic acid

Procedure

The product was obtained starting from cyclobutanecarboxamidine (200 mg, 1.5 mmol) and mucobromic acid (180 mg, 0.7 mmol) according to the method described in intermediate A-4, step 1 as light brown solid (38 mg, 21%).

Workup

customThe product was obtained

Sources & evidence

ORD record: ord-b1abfe33431642a38a499b65f48f480f
Source dataset: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08623866B2

Reaction notes

Loading…