Pyrimidin-5-amine → 2-Cyclobutyl-5-(pyrimidin-5-ylamino)-pyrimidine-4-carboxylic acid (1-methyl-5-methylcarbamoyl-1H-pyrazol-4-yl)-amide

Participants

Reaction Steps

The product was obtained starting from 5-bromo-2-cyclobutyl-pyrimidine-4-carboxylic acid (1-methyl-5-methylcarbamoyl-1H-pyrazol-4-yl)-amide (23 mg, 58 μmol) and 5-aminopyrimidine (8 mg, 82 μmol) according to the method described in example A-1, step 2 after purification by preparative HPLC using an acetonitrile/water gradient as yellow solid (1 mg, 5%).

Provenance & Evidence