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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 467758Generated: October 29, 2026

4-amino-N,1-dimethyl-1H-pyrazole-5-carboxamide → 6-Cyclopropyl-N-(1-methyl-5-(methylcarbamoyl)-1H-pyrazol-4-yl)-3-(pyrazin-2-ylamino)pyrazine-2-carboxamide

https://huagongshe.com/reaction/467758

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-amino-N,1-dimethyl-1H-pyrazole-5-carboxamideHCID 6485370—
ReactantMethyl 6-cyclopropyl-3-(pyrazin-2-ylamino)pyrazine-2-carboxylateHCID 70098647—
Product6-Cyclopropyl-N-(1-methyl-5-(methylcarbamoyl)-1H-pyrazol-4-yl)-3-(pyrazin-2-ylamino)pyrazine-2-carboxamideHCID 54760021—

Reaction Steps

According to the procedure described in step 2 of example 14, methyl 6-cyclopropyl-3-(pyrazin-2-ylamino)pyrazine-2-carboxylate was reacted with 4-amino-N,1-dimethyl-1H-pyrazole-5-carboxamide to give the title compound. Yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08623866B2
Source datasetuspto-grants-2014_01
ORD IDord-61985f711c2c408797f358c5bd5bddf1
Source noteuspto-grants-2014_01