Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
6-Cyclopropyl-3-(pyridin-3-ylamino)pyrazine-2-carboxylic acid → 6-Cyclopropyl-3-(pyridin-3-ylamino)-pyrazine-2-carboxylic acid [5-(azetidine-1-carbonyl)-1-methyl-1H-pyrazol-4-yl]-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 6-Cyclopropyl-3-(pyridin-3-ylamino)pyrazine-2-carboxylic acid | HCID 70096538 | — |
| 반응물 | (4-Amino-2-methyl-2H-pyrazol-3-yl)-azetidin-1-yl-methanone | HCID 70098437 | — |
| 생성물 | 6-Cyclopropyl-3-(pyridin-3-ylamino)-pyrazine-2-carboxylic acid [5-(azetidine-1-carbonyl)-1-methyl-1H-pyrazol-4-yl]-amide | HCID 58548168 | — |
반응 단계
The product was obtained starting from 6-cyclopropyl-3-(pyridin-3-ylamino)pyrazine-2-carboxylic acid (30 mg, 0.12 mmol; example 217, step 2) and (4-amino-2-methyl-2H-pyrazol-3-yl)-azetidin-1-yl-methanone (27 mg, 0.15 mmol) according to the method described in example 64, step 6 after purification by preparative HPLC using an acetonitrile/water gradient as light yellow solid (37 mg, 75%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08623866B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-e58439ae78cf4a468f3f3130c2f507ff |
| 출처 메모 | uspto-grants-2014_01 |