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tert-Butyl 3-aminopyrrolidine-1-carboxylate--hydrogen chloride (1/1) → 3-[(4-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-2-methyl-2H-pyrazole-3-carbonyl)-amino]-pyrrolidine-1-carboxylic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butyl 3-aminopyrrolidine-1-carboxylate--hydrogen chloride (1/1) | HCID 42614159 | — |
| 反応物 | 4-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-2-methyl-2H-pyrazole-3-carboxylic acid | HCID 70098073 | — |
| 生成物 | 3-[(4-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-2-methyl-2H-pyrazole-3-carbonyl)-amino]-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 54761821 | — |
反応手順
The product was obtained starting from 4-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-2-methyl-2H-pyrazole-3-carboxylic acid (30 mg, 79 μmol) and tert-butyl-3-aminopyrrolidine-1-carboxylate hydrochloride (23 mg, 103 μmol) according to the method described in example 64, step 6 after purification by preparative HPLC using an acetonitrile/water gradient as yellow solid (28 mg, 65%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08623866B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-8abcc7dce585483aa55fde80158eeb22 |
| 出典メモ | uspto-grants-2014_01 |