1-Methylpiperidin-3-amine dihydrochloride → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [1-methyl-5-(1-methyl-piperidin-3-ylcarbamoyl)-1H-pyrazol-4-yl]-amide

Participants

Role	Name	HCID	Charge
Reactant	1-Methylpiperidin-3-amine dihydrochloride	HCID 17750342	—
Reactant	4-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-2-methyl-2H-pyrazole-3-carboxylic acid	HCID 70098073	—
Product	6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [1-methyl-5-(1-methyl-piperidin-3-ylcarbamoyl)-1H-pyrazol-4-yl]-amide	HCID 54762014	—

Reaction Steps

The product was obtained starting from 4-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-2-methyl-2H-pyrazole-3-carboxylic acid (25 mg, 66 μmol; example 236, step 3) and 1-methyl-piperidin-3-ylamine dihydrochloride (12 mg, 66 μmol) according to the method described in example 64, step 6 after purification by preparative HPLC using an acetonitrile/water gradient as yellow solid (11 mg, 33%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08623866B2
Source dataset	uspto-grants-2014_01
ORD ID	ord-a0da4f527a9c401097e59a653eb6a250
Source note	uspto-grants-2014_01