Hydrochloric Acid → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [1-methyl-5-(pyrrolidin-3-ylcarbamoyl)-1H-pyrazol-4-yl]-amide

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Reaction Steps

A solution of 3-[(4-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-2-methyl-2H-pyrazole-3-carbonyl)-amino]-pyrrolidine-1-carboxylic acid tert-butyl ester (38 mg, 69 μmol; example 236) in 1,4-dioxane (0.38 ml) was treated with HCl in dioxane (4M; 380 μl, 1.5 mmol) and the reaction mixture was stirred at r.t. for 4 h. The precipitate was filtered off and dried to yield the product as yellow solid (25 mg, 75%).

Provenance & Evidence