反应详情

A solution of 1.68 g of potassium hydroxide in 20 ml of water is added at room temperature to a solution of 6.24 g of 1-acetoxy-2-(4-phenoxyphenoxy)-cyclopentane in 50 ml of ethanol. The mixture is then refluxed for 3 hours and, after cooling, concentrated to 166 of its original volume by rotary evaporation. The residue is poured into ice-water. After extraction with ether, the organic phase is washed three times with saturated sodium chloride solution, dried over sodium sulphate and concentrated by rotary evaporation. Distillation of the residue yields 2-(4-phenoxyphenoxy)-cyclopentan-1-ol as a colourless oil with a boiling point of 181°-185° C./0.001 torr.

1. temperatureThe mixture is then refluxed for 3 hours
2. temperatureafter cooling
3. concentrationconcentrated to 166 of its original volume by rotary evaporation
4. additionThe residue is poured into ice-water
5. extractionAfter extraction with ether
6. washthe organic phase is washed three times with saturated sodium chloride solution
7. dry with materialdried over sodium sulphate
8. concentrationconcentrated by rotary evaporation
9. distillationDistillation of the residue