HCID 70099521, compound → HCID 70098131, compound

HRID 467796Notes

Reaction equation

HRID 467796 reaction equation
[OH:1][C:2]([CH3:18])([CH3:17])[CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([N+:14]([O-])=O)=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11]>C(O)C.[Pd]>[NH2:14][C:8]1[CH:7]=[CH:6][C:5]([O:4][CH2:3][C:2]([OH:1])([CH3:17])[CH3:18])=[CH:13][C:9]=1[C:10]([OH:12])=[O:11]

Participants

4

Reactant 1

HCID 70099521HCID 70099521, compound

Product 1

HCID 70098131HCID 70098131, compoundYield 99.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 5-(2-hydroxy-2-methylpropoxy)-2-nitrobenzoic acid (0.145 g, 568 μmol) in ethanol (5 ml) was hydrogenated at normal pressure in the presence of 20 mg Pd/C 10% at r.t overnight. The catalyst was filtered and washed with EtOH. The filtrate was concentrated to give the title compound (127 mg, 99%) as grayish foam.

Workup

  1. filtrationThe catalyst was filtered
  2. washwashed with EtOH
  3. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-5a5bbc4df2e64295b3ee7fbe678e12da
Source dataset
uspto-grants-2014_01
Patent number
US08623866B2

Reaction notes

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