反应详情

20 g (153 mmol) 2-thiouracil are suspended in 250 mL MeOH and then 8.7 g (152.9 mmol, 1 eq) sodium methoxide are added. The solution is stirred for 5 min at RT and then 12.4 mL (198.8 mmol, 1.3 eq) methyl iodide are added dropwise. The reaction mixture is stirred overnight, then poured onto water and extracted 3× with approx. 150 mL chloroform. The combined organic phases are dried on MgSO4, the solvent is eliminated in vacuo and 16 g E-1 are obtained.

1. stirringThe reaction mixture is stirred overnight
2. additionpoured onto water
3. extractionextracted 3× with approx. 150 mL chloroform
4. customThe combined organic phases are dried on MgSO4
5. customare obtained