反应详情

To a solution of 2-amino-3-bromo-5-(trifluoromethyl)pyridine (10.0 g, 41.5 mmol) in 1,2 dimethoxyethane (300 mL) at room temperature was added ethyl bromopyruvate (9.889 g, 45.64 mmol) dropwise. The reaction mixture was heated to reflux for 18 h. The 1,2-dimethoxyethane was removed under reduced pressure and the residual solid was recrystallized from 1-chlorobutane. The solid was isolated by filtration and dried to afford an off-white solid, 8-bromo-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid, ethyl ester (11.044 g).

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 18 h
3. customThe 1,2-dimethoxyethane was removed under reduced pressure
4. customthe residual solid was recrystallized from 1-chlorobutane
5. customThe solid was isolated by filtration
6. customdried