反应详情

A solution of 18.0 g (84.4 mmol) of 2,6-dichloronicotinic acid in 180 ml (3.45 mol) of a 70% solution of ethylamine in water is heated at 50° C. for 10 hours. The excess amine is then evaporated under reduced pressure, then a 10% aqueous solution of acetic acid is added until the product is precipitated. The beige solid is filtered, rinsed with cold water and stove-dried. 10.5 g of the expected product is obtained. Yield=62%. Melting point: 158-160° C. MH+: 201.1 (Tr: 7.7 min, condition 1).

1. customThe excess amine is then evaporated under reduced pressure
2. additiona 10% aqueous solution of acetic acid is added until the product
3. customis precipitated
4. filtrationThe beige solid is filtered
5. washrinsed with cold water
6. customstove-dried