HCID 53261927, compound → HCID 53251081, compound

Participants

Reaction Conditions

Reaction Steps

A round-bottom flask under inert atmosphere is loaded with 26 g of the oily product from Example 3, and 100 g of a 1:1 methanol/water mixture. The mixture is stirred to complete dissolution, then added with 2.6 g of 10% Pd/C. A washing cycle is carried out under nitrogen-vacuum, then the mixture is heated to 40° C. and hydrogen is slowly bubbled therein until complete disappearance of the starting product. The mixture is cooled to 30° C. and the catalyst is filtered off through a celite pad, washing twice with a methanol-water mixture. The solvent is evaporated off and the residue is repeatedly taken up with isobutanol and evaporated to obtain 9 g of a white solid.

Provenance & Evidence