Dimethylformamide → HCID 58049414, compound

Participants

Reaction Steps

A mixture of N-(3-bromo-4-fluorobenzyl)-1-methyl-N-(tetrahydro-2H-pyran-4-yl)-1H-imidazole-4-carboxamide (150 mg), phenylboronic acid (92 mg), tetrakis(triphenylphosphine)palladium (50 mg), potassium carbonate (110 mg), DMF (2 mL) and ethanol (1 mL) was subjected to reaction in a microwave reactor (150° C., 10 min). Water was added to the reaction mixture, followed by extraction with ethyl acetate and concentrating under reduced pressure. The resulting residue was purified by TLC (silica gel) (chloroform:methanol=10:1) to give the titled compound (50 mg).

Provenance & Evidence