Ethanol → HCID 58049365, compound

Participants

Reaction Steps

A mixture of methyl 2′-fluoro-5′-([[(1-methyl-1H-1,2,4-triazol-3-yl)carbonyl](tetrahydro-2H-pyran-4-yl)amino]methyl)biphenyl-3-carboxylate (318 mg), ethanol (14 mL) and sodium borohydride (532 mg) was heated under reflux for 16 hours. After leaving the mixture to cool, water-acetone was added and extraction was conducted with chloroform. The organic layer was dried over anhydrous sodium sulfate. After filtering off the desiccant, the solvents were distilled off under reduced pressure and the resulting residue was purified by column chromatography (silica gel cartridge; methanol/chloroform=1:99 to 3:97) to give the titled compound (17 mg).

Provenance & Evidence